事業内容

特許・論文

特許

糖尿病性腎症関連
権利取得済の特許が2件、出願中の特許が2件
アレルギー関連
出願中の特許が1件
研究開発実績:学術論文
48件

論文

糖尿病性腎症関連

Urinary IgG4 and Smad1 Are Specific Biomarkers for Renal Structural and Functional Changes in Early Stages of Diabetic Nephropathy.

Doi T, Moriya T, Fujita Y, Minagawa N, Usami M, Sasaki T, Abe H, Kishi S, Murakami T, Ouchi M, Ichien G, Yamamoto K, Ikeda H, Koezuka Y, Takamatsu N, Shima K, Mauer M, Nagai K, Tominaga T.
Diabetes. 2018 May;67(5):986-993. doi: 10.2337/db17-1043. Epub 2018 Feb 28.

Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study.

Kishi F, Nagai K, Takamatsu N, Tominaga T, Tamaki M, Shibata E, Murakami T, Kishi S, Abe H, Koezuka Y, Minagawa N, Ichien G, Doi T.
PLoS One. 2018 Apr 6;13(4):e0195523. doi: 10.1371/journal.pone.0195523.

All-trans retinoic acid suppresses bone morphogenetic protein 4 in mouse diabetic nephropathy through a unique retinoic acid response element. American Journal of Physiology-Endocrinology and Metabolism, 316, E418?E431.

Tamaki, M., Tominaga, T., Fujita, Y., Koezuka, Y., Ichien, G., Murakami, T., Kishi, S., Yamamoto, K., Abe, H., Nagai, K. and Doi, T. (2019).

アレルギー関連

IgE-class-specific immunosuppression in offspring by administration of anti-IgE to pregnant mice.

Morita H, Tamari M, Fujiwara M, Motomura K, Koezuka Y, Ichien G, Matsumoto K, Ishizaka K, Saito H.
J Allergy Clin Immunol. 2019 Mar;143(3):1261-1264.e6. doi: 10.1016/j.jaci.2018.11.008. Epub 2018 Nov 22.

研究開発実績:学術論文

1. Muramatsu, M. (2001). Toxicogenomics in the post-genome era. The Journal of Toxicological Sciences, 26(4), 201.


2. Kato, Masaki., Seki, Naohiko., Sugano, Sumio., Hashimoto, Katsuyuki., Masuho, Yasuhiko., Muramatsu, M. and Kaibuchi, Kozo. (2001). Identification of Sonic Hedgehog-Responsive Genes using cDNA microarray. Biochemical and Biophysical Research Communications, 289, 472–478.


3. 東 陽子, 佐藤 新, 樋口 裕高, 坂野 鋭, 森本 俊彦, 松永 務, 石井 敬介, 村松 正明 (2002). クラスタリングによる遺伝子解析 : 遺伝子型の自動分類(The genotype analysis with clustering : Automatic classification of genotype). 電子情報通信学会技術研究報告. WIT, 福祉情報工学, 102(319), 7–10.


4. 村松 正明, 内藤 隆宏 (2003). ヒトゲノムとその多様性SNPの医療への応用(Variation of human genome and application of SNP to medicine). 電子情報通信学会技術研究報告. PRMU, パターン認識・メディア理解. 103(150), 35–40.


5. Higashi, Y., Higuchi, H., Kido, T., Matsumine, H., Baba, M., Morimoto, T. and Muramatsu, M. (2003). SNP analysis system for detecting complex disease associated sites. Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003.


6. Kido, T., Baba, M., Matsumine, H., Higashi, Y., Higuchi, H. and Muramatsu, M. (2003). Haplotype pattern mining & classification for detecting disease associated site. Computational Systems Bioinformatics. CSB2003. Proceedings of the 2003 IEEE Bioinformatics Conference. CSB2003.


7. Inoue, F., Kuga, H., Eguchi, K., Muramatsu, M., Ichien, G., Kitamura, S., Tomoike, H. and Kitakaze, M. (2004). 健康増進運動と心血管疾患予防 西有田町における生活習慣調査,生化学的検査及び遺伝情報から生活習慣病の個々の危険因子を探索する新しい計画 (Health Promotion Act and Cardiovascular Disease Prevention: A new strategy for fishing individual risk factors of life-style related disease in lifestyle, biochemical data and genomics in Nishiarita). Circulation journal : official journal of the Japanese Circulation Society, 68(Supplement_I), 24. Retreieved from https://ci.nii.ac.jp/naid/110002699834/


8. Hirano, M. (2004). RACE using only a gene-specific primer-application of a template-switching model. Molecular Biotechnology, 27, 179–186.


9. Suzuki, A., Ji, G., Numabe, Y., Ishii, K., Muramatsu, M. and Kamoi, K. (2004). Odontology, 92, 43–47.


10. 斎藤 貴史, 新沢 陽英, 冨樫 整, 村松 正明, 河田 純男 (2005). 肝検診地域の住民におけるC型肝炎ウイルス感染感受性遺伝子の解析. 日本消化器集団検診学会雑誌, 43 (1), 13–19.


11. Kido, T., Baba, M., Ji, G., Satoh, H., and Muramatsu, M. (2005)Mapping SNP association results into type 2 DM pathways-metabolic syndrome as a robust system. 2005 IEEE Computational Systems Bioinformatics Conference - Workshops (CSBW'05).


12. Geshi, E., Kimura, T., Yoshimura, M., Suzuki, H., Koba, S., Sakai, T., Saito, T., Koga, A., Muramatsu, M. and Katagiri, T. (2005). A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity. Hypertension Research, 28, 719–725.


13. Kato, N., Ji, G., Wang, Y., Baba, M., Hoshida, Y., Otsuka, M., Taniguchi, H., Moriyama, M., Dharel, N., Goto, T., Shao, R., Matsuura, T., Ishii, K., Shiina, S., Kawabe, T., Muramatsu, M. and Omata, M. (2005). Hepatology, 42(4), 846–853.


14. Daimon, M., Ji, G., Oizumi, T., Kido, T., Baba, Ma., Jimbu, Y., Kameda, W., Susa, S., Yamaguchi, H., Ohnuma, H., Muramatsu, M. and Kato, T. (2006). Association of nephrin gene polymorphisms with type 2 diabetes in a Japanese population. Diabetes Care, 29(5), 1117–1119.


15. Kawasaki, R., Ji, G., Taylor, B., Wang, J.J., Wong, T.Y., Yamashita, H., Mitchell, P., 21st century COE study group and Yamagata University (2006). Prevalence of age–related maculopathy in an adult Japanese population: The Funagata Study. Investigative Ophthalmology & Visual Science, 47(13), 2211.


16. Sato, H., Kawasaki, R., Ji, Guijin., Taylor, B., Wang, J.J., Wong, T.Y., Yamashita, H., Mitchel, P., 21st Century COE Study Group and Yamagata University (2006). Prevalence of epiretinal membranes in an adult Japanese population: The Funagata Study. Investigative Ophthalmology & Visual Science, 47(13), 5639.


17. Kimura, T., Saito, T., Yoshimura, M., Song. Y,, Baba, M., Ji, G., Muramatsu, M. and Kawata, S. (2006). Association of transforming growth factor–β1 functional polymorphisms with natural clearance of hepatitis C virus. The Journal of Infectious Diseases, 193(10), 1371–1374.


18. Takabatake, N., Shibata, Y., Abe, S., Wada, T., Machiya, J., Igarashi, A., Tokairin, Y., Ji, G., Sato, H., Sata, M., Takeishi, Y., Emi, M., Muramatsu, M. and Kubota, I. (2006). A single nucleotide polymorphism in the CCL1 gene predicts acute exacerbations in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine, 174(8), 875–885.


19. Kido, T. (2006). A haplotype analysis system for genes discovery of common diseases. In H. Hsu (Ed.). Advanced data mining technologies in bioinformatics (1st ed., pp. 214–230). Pennsylvania, PA: Idea Group Publishing.


20. Miyata, M., Yamamoto, T., Komori, T., Nitta, N. (2007). Marker-assisted selection and evaluation of the QTL for stigma exsertion under japonica rice genetic background. Theoretical and Applied Genetics, 114, 539–548.


21. Sata, M., Takabatake, N., Inoue, S., Shibata, Y., Abe, S., Machiya, J., Wada, T., Ji, G., Kido, T., Matsuura, T., Muramatsu, M. and Kubota, I. (2007). Intronic single‐nucleotide polymorphisms in Bcl‐2 are associated with chronic obstructive pulmonary disease severity. Respirology, 12, 34–41.


22. Matsunaga, T., and Muramatsu, M. (2007). Disease-related concept minig by knowledge-based two-dimensional gene mapping. Journal of Bioinformatics and Computational Biology, 5(5), 1047–1067.


23. Konta, T., Emi, M., Toriyama, S., Ariumi, H., Ishii, M., Takasaki, S., Ikeda, A., Ichikawa, K., Shibata, Y., Takabatake, N., Takeishi, Y., Kato, T., Kawata, S. and Kubota, I. (2008). Association of CC chemokine ligand 5 genotype with urinary albumin excretion in the non-diabetic Japanese general population: the Takahata study. Journal of Human Genetics, 53, 267–274.


24. Iijima, H., Emi, M., Wada, M., Daimon, M., Toriyama, S., Koyano, S., Sato, H., Hopkins, P. N., Hunt, S.C., Kubota, I., Kawata, S. and Kato, T. (2008). Association of an intronic haplotype of the LIPC gene with hyperalphalipoproteinemia in two independent populations. Journal of Human Genetics, 53, 193–200.


25. Koyano, S., Emi, M., Saito, T., Makino, N., Toriyama, S., Ishii, M., Kubota, I., Kato, T. and Kawata, S. (2008). Common null variant, Arg192Stop, in a G‐protein coupled receptor, olfactory receptor 1B1, associated with decreased serum cholinesterase activity. Hepatology Research, 38, 696–703.


26. Mori, S., Kou, I., Sato, H., Emi, M., Ito, H., Hosoi, T. and Ikegawa, S. (2008). Association of genetic variations of genes encoding thrombospondin, type 1, domain-containing 4 and 7A with low bone mineral density in Japanese women with osteoporosis. Journal of Human Genetics, 53, 694–697.


27. Hirano, M. (2008). Natural Grp78 antisense RNA induces apoptosis by creating a chimeric. In R.H. Fenton and C.V. Burnside (Ed.). Cell Apoptosis Research Progress (1st ed., pp. 167–209). New York, NY: New York Nova Biomed.


28. Kido, T. (2008a). A haplotype analysis system for genes discovery of common diseases. In J. Wang (Ed.). Data Warehousing and Mining: Concepts, Methodologies, Tools, and Applications (1st ed., pp. 1674–1687). Pennsylvania, PA: Idea Group Publishing.


29. Kido, T. (2008b). A haplotype analysis system for genes discovery of common diseases. In V. Sugumaran (Ed.). Intelligent Information Technologies: Concepts, Methodologies, Tools, and Applications (1st ed., pp. 590–604). Pennsylvania, PA: Information Science Reference.


30. Kido, T. (2009). A haplotype analysis system for genes discovery of common diseases. In J. Tang (Ed.). Medical Informatics: Concepts, Methodologies, Tools, and Applications (1st ed., pp. 2109–2122). Pennsylvania, PA: Information Science Reference.


31. Mori, S., Kou, I., Sato, H., Emi, M., Ito, H., Hosoi, T. and Ikegawa, S. (2009). Nucleotide variations in genes encoding carbonic anhydrase 8 and 10 associated with femoral bone mineral density in Japanese female with osteoporosis. Jourmal of Bone and Mineral Metabolism, 27, 213–216.


32. Matsunaga, T., Yonemori, C., Tomita, E. and Muramatsu, M. (2009). Clique-based data mining for related genes in a biomedical database. BMC Bioinformatics, 10, 205–223.


33. Matsubara, T., Koyano, S., Funahashi, K., Toriyama, S., Nakahara, K., Hagiwara, T., Miura, T., Okuda, K., Sagawa, A., Sakurai, T., Matsuno, H., Izumihara, T. and Shono, E. (2009). An Algorithm Using Genome-Wide SNP Analysis for Prediction of Responders and Non-Responders, and Adverse Events in Tocilizumab-Treated RA Patients. ACR/ARHP Scientific Meeting 09.


34. Takamatsu, N., Abe, H., Tominaga, T., Nakahara., K., Ito, Y., Okumoto, Y., Kim, J., Kitakaze, M. and Doi, T. (2009). Risk factors for chronic kidney disease in Japan: a community based study. BMC Nephrology,10, 34–43.


35. 末永 高志, 松永 務, 関根 純, 村松正明 (2009). テキストマイニングのためのドメイン別単語辞書の構築方法. 情報処理学会研究報告, 2009-BIO-19, 23, 1–6.


36. Matsunaga, T., Kuwata, S. and Muramatsu, M. (2010). Computational gene knockout reveals transdisease-transgene association structure. Journal of Bioinformatics and Computational Biology, 8(5), 843–866.


37. Konta, T., Takasaki, S., Ichikawa, K., Emi, M., Toriyama, S., Satoh, H., Ikeda, A., Suzuki, K., Mashima, Y., Shibata, Y., Watanabe, T., Kato, T., Kawata, S. and Kubota, I. (2010). The novel and independent association between single-point SNP of NPHP4 gene and renal function in non-diabetic Japanese population: the Takahata study. Journal of Human Genetics, 55, 791–795.


38. Karasawa, S., Daimon, K., Sasaki, S., Toriyama, S., Oizumi, T., Susa, S., Kameda, W., Wada, K., Muramatsu, M., Gukao, A., Kubota, I., Kawata, S., Kayama, T. and Kato, T. (2010). Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population. Endocrine Journal 2010, 57(4), 293–301.


39. Tominaga, T., Abe, H., Ueda, O., Goto, C., Nakahara, K., Murakami, T., Matsubara, T., Mima, A., Nagai, K., Araoka, T., Kishi, S., Fukushima, N., Hishage, K. and Doi, T. (2011). Activation of bone morphogenetic protein 4 signaling leads to glomerulosclerosis that mimics diabetic nephropathy. The Journal of Biological Chemistry, 286(22), 20109–20116.


40. Chen, C., Asakura, M., Asanuma, H., Hasegawa, T., Tanaka, J., Toh, N., Min, K., Kanzaki, H., Takahama, H., Amaki, M., Itoh, Y., Ichien, G., Okumoto, Y., Funahashi, T., Kim, J. and Kitakaze, M. (2012). Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels. Hypertension Research, 35, 843–848.


41. Daimon, M., Sato, H., Kaino, W., Tada, K., Takase, K., Karasawa, S., Wada, K., Kameda, W., Susa, S., Oizumi, T., Kayama, T., Muramatsu, M. and Kato, T. (2913). Association of the G-protein β3 subunit gene polymorphism with the incidence of cardiovascular disease independent of hypertension: the Funagata study. Journal of Human Hypertension, 27, 612–616.


42. Ide, T., Suzuki, A., Kurokawa, M., Minagawa, N., Inuzuka, H. and Ichien, G. (2016). Analysis of effects of kale powder consumption among subjects with potential metabolic syndrome: A prospective single-arm clinical study. Journal of Hypertension and Cardiology, 2(2), 25–38.


43. Nagai, K., Tsuchida, K., Ishihara, N., Minagawa, N., Ichien, G., Yamada, S., Hirose, D., Michiwaki, H., Kanayama, H., Doi, T. and Minakuchi, J. (2017). Implications of albumin leakage for survival in maintenance hemodialysis patients: A 7-year observational study. Therapeutic Apheresis and Dialysis, 21(4), 378–386.


44. Nagai, K., Tsuchida, K., Ishihara, N., Minagawa, N., Ichien, G., Yamada, S., Hirose, D., Michiwaki, H., Kanayama, H., Doi, T. and Minakuchi, J. (2018). Author's Reply to Oka and Colleagues. Therapeutic Apheresis and Dialysis, 22(1),96–97.


45. Kishi, F., Nagai, K., Takamatsu, N., Tominaga, T., Tamaki, M., Shibata, E., Murakami, T., Kishi, S., Abe, H., Koezuka, Y., Minagawa, N., Ichien, G. and Doi, T. (2018). Urinary type IV collagen excretion is involved in the decline in estimated glomerular filtration rate in the Japanese general population without diabetes: A 5-year observational study. PLOS ONE, 13(6): e0199401.


46. Doi, T., Moriya, T., Fujita, Y., Minagawa, N., Usami, M., Sasaki, T., Abe, H., Kishi, S., Murakami, T., Ouchi, M., Ichien, G., Yamamoto, K., Ikeda, H., Koezuka, Y., Takamatsy, N., Chima, K., Mauer, M., Nagai, K. and Tominaga, T. (2018). Urinary IgG4 and Smad1 are specific biomarkers for renal structural and functional changes in early stages of diabetic nephropathy. Diabetes, 67 (5), 986–993.


47. Morita, H ., Tamari, M., Fujiwara, M., Motomura, K., Koezuka, Y., Ichien, G., Matsumoto, K., Ishizaka, K. and Saito, H. (2018). IgE-class–specific immunosuppression in offspring by administration of anti-IgE to pregnant mice. Journal of Allergy and Clinical Immunology, 143(3), 1261–1264.


48. Tamaki, M., Tominaga, T., Fujita, Y., Koezuka, Y., Ichien, G., Murakami, T., Kishi, S., Yamamoto, K., Abe, H., Nagai, K. and Doi, T. (2019). All-trans retinoic acid suppresses bone morphogenetic protein 4 in mouse diabetic nephropathy through a unique retinoic acid response element. American Journal of Physiology-Endocrinology and Metabolism, 316, E418ーE431.


※赤字:当社所属研究者 ※最新整理日:2020/7/15

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